范瑞芳，女，河南省新鄉(xiāng)人，博士,，華南師范大學生命科學學院教授,，博士研究生導師,。任廣東省環(huán)境誘變劑協(xié)會理事, 長期擔任Environment International, Environmental Science & Technology, Science of Total Environment, Environmental Research, Scientific Reports, Chemosphere等雜志的審稿人,。
在國內(nèi)外發(fā)表中英文論文50余篇,，其中30篇被SCI及EI收錄,，“羧甲基聚合β－CD作為手性劑分離維拉帕米和布比卡因”一文獲“第四屆全國毛細管電泳及相關(guān)微分離分析技術(shù)學術(shù)報告會組委會”大會論文一等獎,，曾獲得華南師范大學科研工作優(yōu)秀獎等榮譽，培養(yǎng)的多名研究生獲得“廣東省優(yōu)秀學生”和“國家獎學金”等,。
研究興趣：（1）環(huán)境有機污染物生物監(jiān)測與環(huán)境風險評價（2）環(huán)境污染物的毒理與健康效應(yīng),。歡迎具有環(huán)境科學、生物技術(shù)、環(huán)境毒理學背景的學生報考研究生,。電子郵件：[email protected] 和 [email protected]
Researches interested
[1] The biomonitoring of environmental pollutions in urine and blood for populations and the assessment of their environmental risks.
[2] Environmental toxic mechanism and its health effects.
研究工作經(jīng)歷：
2014.12-今,，華南師范大學生命科學學院，教授,。
2010.09-2012.03,，獲國家留學基金委資助，赴美國加州公共衛(wèi)生局（California Department of Public Health）訪學一年半,。
2006.12-2014.12,，華南師范大學生命科學學院，副教授,。
2001.12-2006.11,，華南師范大學生命科學學院，助理研究員,。
2000.03-2001.11,，華南師范大學生命科學學院，實習研究員,。
教育經(jīng)歷：
2004.03-2007.06,，中科院廣州地球化學研究所，博士,。
1997.09-2000.02,，北京理工大學，碩士,。
1991.09-1995.06,，河南師范大學，本科,。
近5年主持/參與的國家、省部級基金項目有：
[1] 國家自然科學基金（21777048）,，2018.01-2021.12,，64萬元，主持,，在研,。
[2] 國家自然科學基金重點項目（41731279），2018.01-2022.12,，323萬元,，第一參與人/子課題負責人，在研,。
[3] 廣州市科技計劃項目(201510010107),，20萬，2015.06-2018.06,，主持,，結(jié)題,。
[4] 國家自然科學基金(21477041)，87萬元,，2015.01-2018.12,，主持，結(jié)題,。
[5] 廣東省自然科學基金(S2013010013183),，5萬元，2013.10-2015.10,，主持,，結(jié)題。
[6] 教育部留學回國人員科研啟動基金(教外司留[2013]693號),，3萬元,，2013.07-2015.07，主持,，結(jié)題,。
[7] 教育部博士點基金(20124407120005)，4萬元,，2012.12-2015.12,，主持，結(jié)題,。
[8] 環(huán)境保護部全國重點地區(qū)環(huán)境與健康專項調(diào)查基金子課題(21111011101EHH(2011)-206),，8萬元，2011.07-2013.02,，主持,，結(jié)題。
Research fundings:
【1】 Effects of low-dose and perinatal exposure to bisphenol A on brain cell of offspring mice as well as its relationships with altered behavior of children, supported by National Natural Science Foundation of China (grant No. 21777048), ￥640,000, 2017.01-2020.12.
【2】Effects of long-term and low-dose exposure to bisphenol A on brain cell and behavior in several generations of mice during perinatal period, supported by the Guangzhou Key Laboratory of Environmental Exposure and Health (grant No. GZKLEEH201607), ￥50,000, 2016.06-2018.06.
【3】Relationships between polycyclic aromatic hydrocarbon exposure levels and DNA damage, lung function of children, supported by National Natural Science Foundation of China (grant No.21477041), ￥870,000, 2015.01-2018.12.
【4】Effects of Long-term exposure to bisphenol A on brain cell and their relationships with the change of children behavior, supported by Science and Technology Program of Guangzhou, China (grant No.201510010107), ￥200,000, 2015.01-2017.12.
【5】Relationships between the urinary bisphenol A exposure for kindergarten children in Guangzhou, the oxidative DNA damage and the dust concentration, supported by Natural Science Foundation of Guangdong, China (grant No. S2013010013183), ￥50,000, 2013.10-2015.10.
【6】Primary study of aromatic carcinogenic compounds in PM2.5 air and its effects on children in Guangzhou, Supported by Scientific Research Foundation for Returned Scholars, Ministry of Education of China (grant No. [2013] 693), ￥30,000, 2013-2015.
【7】 Primary study of aromatic carcinogenic compounds in PM2.5 air and its effects on children in Guangzhou, supported by Research Fund for the Doctoral Program of Higher Education of China (grant No. 20124407120005), ￥40,000, 2013.0-2015.05.
【8】 QA/QC system of the quantitation of hydroxyl PAH in urine, supported by Ministry of Environmental Protection, sub-funding of environmental health special survey of the key area of China (grant No. 21111011101EHH(2011)-206), ￥80,000, 2011.10-213.02.
【9】 Children’s exposure level to PAHs in Guangzhou and their relationships with DNA damage, supported by Open Project of Chinese state key laboratory of organic chemistry (grant No OGL-200706). ￥20,000, 2008.01-2009.12.
近年以通訊以及第一作者發(fā)表的代表性文章(Publications in the past five years):
(1) Haibin Zhang, Zhouyu Wang, Lingxue Meng, Hongxuan Kuang, Jian Liu, Xuejing Lv, Qihua Pang, Ruifang Fan*, Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations, Toxicology, 2020, 432:152393.
(2) Hongxuan Kuang, Yanyan Dai, Yonghong Li, Caihui Cha, Wenhui Jiang, Qihua Pang, Haibin Zhang, Ruifang Fan*. The association among blood BPDE-DNA adducts, serum interleukin-8 (IL-8) and overall DNA damage for children with pulmonary disease. International Journal of Environmental Health Research,, 2019, 1-12. (SCI, IF=1.465)
(3) Hongxuan Kuang, Yonghong Li, Wenhui Jiang, Peiqiong Wu, Jianhua Tan, Haibin Zhang, Qihua Pang, Ruifang Fan*. Simultaneous determination of urinary 31VOC metabolites, 8-hydroxy-2'-deoxyguanosine and trans-3'-hydroxy-cotinine by UPLC-MS/MS: The effect of isotoped internal standards on elimination of matrix effect, Analytical and Bioanalytical Chemistry, 2019, 411:7841-7855. (IF2018=3.286)
(4) Haibing Zhang, Kuanghong Xuan, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fan*. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats, Science of the Total Environment, 2019, 697:134036. （ IF2018=5.589）
6) 鄺洪軒,，張海彬，譚建華,，雒亦凡,，劉舒華，龐啟華,，李楚華,，范瑞芳*. 維生素C抗氧化-同位素內(nèi)標稀釋-超高效液相色譜串聯(lián)質(zhì)譜法同時測定新生期大鼠海馬體神經(jīng)遞質(zhì)的含量，色譜,，2019,，37（4）：404-411。
(7) Laiguo Chen, Guocheng Hu, Ruifang Fan*, Yanshan Lv, Yanyan Dai, Zhencheng Xu*. Association of PAHs and BTEX exposure with lung function and respiratory symptoms among non-occupational population near the coal-chemical industry in Northern China. Environment International, 2018, 120:480-488. (SCI2018=7.943, 1區(qū))
(8) Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan*, Caihui Cha*, Guanyong Li, Zhiwei Luo, Qihua Pang. Relationship between Bisphenol A exposure and Attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution, 2018, 235:141-149. (SCI2018=5.714, 2區(qū))
(9) Yuanxiu Zhou, Zhouyu Wang, Minghan Xia, Siyi Zhuang, Xiaobing Gong*, Jianwen Pan, Chuhua Li, Ruifang Fan*, Qihuang Pang, Shaoyou Lu. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: An implication for children exposed to environmental level of BPA, Environmental Pollution, 2017, 229:40-48. (SCI2017=4.358, 2區(qū))
(10) Yanshan Lv#, Shaoyou Lu#, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yanru Li, Yuanxiu Zhou, Qihua Pang, Ruifang Fan*. Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage, Environment International, 2017, 98:69-74. SCI2017=7.297, 1區(qū)).
(11) Yanshan Lv, Caiyan Rui, Yanyan Dai, Qihua Pang, Yanru Li, Ruifang Fan*, Shaoyou Lu*. Children exposure to BPA through dust and the association of urinary BPA, triclosan with oxidative stress in Guangzhou, China. Environmental Science: processes & impact, 2016, 18: 1492-1499. (SCI, IF2016=2.592)
(12) Shaoyou Lu, Lu Ren, Jianzhang Fang, Jiajia Ji, Guihua Liu, Jianqing Zhang, Huimin Zhang, Ruorong Luo, Kai Lin, Ruifang Fan*. Trace elements can increase urinary 8-hydroxy
(13)周苑秀，李敏杰,，鐘偉紅, 范瑞芳*. 彗星電泳法測定雙酚A對雄性小鼠腦細胞的DNA損傷.生態(tài)毒理學報,，2016，11(2):666-671,。
(14) Junnan Li#, Shaoyou Lu#, Guihua Liu, Yuanxiu Zhou,Yan Shan Lv, Jianwen She, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene and their dose-effects on oxidative stress damage in kindergarten-aged children in Guangzhou, China. Science of the Total Environment, 2015, 524-525: 74-80. (SCI, IF2015=4.099, 2區(qū)).
(15)Ruifang Fan*, Biyan Zeng, Xiaosu Liu, Chao Chen, Qinwei Zhuang, Yongjun Wang, Mingli Hu, Yanshan Lv, Junnan Li, Yuanxiu Zhou, Zhi Yuan (William) Lin. Levels of bisphenol-A in different paper products in Guangzhou, China and assessment of human exposure via dermal contact. Environmental Science: Processes & Impacts, 2015, 17:667-673. (SCI, IF2015=2. 401)
(16) Ruifang Fan*, Dongli Wang, Jianwen She. Method development for the simultaneous analysis of trans, trans-muconic acid, 1, 2-dihydroxybenzene, S-phenylmercapturic acid and S-benzylmercapturic acid in human urine by liquid chromatography/tandem mass spectrometery. Analytical Methods, 2015, 7: 573-580. (SCI, IF2015=1.821)
(17)Junnan Li, Ruifang Fan*, Shaoyou Lu*, Dongru Zhang,，Yuanxiu Zhou, Yanshan Lv. Exposure to Polycyclic Aromatic Hydrocarbon could cause their oxidative DNA Damage: A Case Study for College Students in Guangzhou, China. Environmental Science and Pollution Research, 2015, 22: 1770-1777. (SCI, IF2015=2.828)
(18) Ruifang Fan, Junnan Li, Laiguo Chen*, Zhencheng Xu*, Dechun He, Yuanxiu Zhou, Yuanyuan Zhu, Fusheng Wei , Jihua Li. Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene. Environmental Research, 2014, 135: 1–8. (SCI, IF2014=4.373)
(19) Ruifang Fan*, Dongli Wang, Chuanwei Mao, Shangkang Ou, Zhixia Lian, Shaoling Huang, Qiongshan Lin, Runhao Ding, Jianwen She. Preliminary study of children’s exposure to PAHs and its association with 8-hydroxy-2’-deoxyguanasine in Guangzhou, China. Environment International, 2012, 42: 53-58. (SCI, IF2012 = 6.248)
(20) Ruifang Fan, Robert Ramage, Dongli Wang, Junqiang Zhou, Jianwen She*. Determination of ten monohydroxylated polycyclic aromatic hydrocarbons by liquid-liquid extraction and liquid chromatography/tandem mass spectrometry. Talanta, 2012, 93: 383-395. (SCI, IF2012 = 3.498)
(21)Ruifang Fan, Dongli Wang, Robert Ramage, Jianwen She*. Fast and simultaneous determination of urinary 8-hydroxy-2'-deoxyguanosine and ten monohydroxylated polycyclic aromatic hydrocarbons by liquid chromatography/tandem mass spectrometery. Chemical Research in Toxicology, 2012, 25(2) 491-499. (SCI, IF2012= 3.667.)
國家發(fā)明專利 (Patents)：
范瑞芳，液相色譜串聯(lián)質(zhì)譜分析尿液中苯和甲苯四種代謝產(chǎn)物的方法,，授權(quán)專利號：ZL-201310067770.3,，授權(quán)日期：2014年4月2日。
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